multiple regression of the data of PDE and the transformed values of the three independent variables. Approximately.2- and.5-fold increase in skin drug retention in LIG-1 and LIG-2, respectively, was determined. Buy the Full Version, you're Reading a Free Preview, pages 99 to 113 are not shown in this preview. The skin retention of IDU was enhanced due to its entrapment in the liposomal vesicles. The three independent variables selected were volume of organic phase (x1 volume of aqueous phase (x2 and in molar ratio (x3). Batch 14 (Lipo-14) was found to have maximum PDE.4. A comparative diffusion study of LIG-1 and LIG-2 with PIG-1 and PIG-2 (1w/w IDU with components of liposome dispersed in 2w/w and 5w/w hpmc K4M gel bases, respectively respectively, through human cadaver skin was conducted.
Stability evaluation of liposomal gels. The paper is issued from Pharm. Thesis of Ali Balouchi and financially. Uploaded by Rishikesh Chakor. The work embodied in this thesis is original and has not been submitted the basis for the award of degree.
The optimization of the method of preparation of idoxuridine (IDU) liposomes by the reverse phase evaporation (REV) method was carried out by three variables at three levels (3(3) factorial design. A double blind clinical study demonstrated an approximately.0- and.6-fold increase in average percentage improvement in healing of the lesions in patients suffering from HSV-1 and HSV-2 diseases, respectively, when treated with billy elliot character essay LIG-2 compared with PIG-2. The study also demonstrated that IDU liposomal gels retain more drug when compared with plain liposomes at all temperatures for the period of three months, while maximum PDR was found at refrigeration temperature. The clinical study suggested the improvement of therapeutic efficacy of IDU entrapped in liposomes in treatment of HSV-1 and HSV-2 patients. The PDR study showed maximum drug retention at 2-8 degrees. In the diffusion studies, a significant (p.05) flux reduction;.5 times in LIG-1 when compared with PIG-1 and.3 times in LIG-2 when compared with PIG-2 was observed. Buy the Full Version, you're Reading a Free Preview, pages 44 to 95 are not shown in this preview. However, complete removal of lesions was not observed. Three contour plots at fixed level of- 1 (low 0 (medium and 1 (high) of major contributing variable (x3) were plotted between x1 and x2 at predetermined PDE to understand the physical meaning of independent variables. A significant increase in PDR (p.05) was observed in LIG-1 and LIG-2 when compared with Lipo-14 at all the three temperatures. The percentage of drug retention (PDR) studies of optimized batch 14 (Lipo-14) and LIG-1 and LIG-2 were carried out at three different storage conditions (2-8 degrees C, 25 /- 2 degrees C, and 37 degrees C). Buy the Full Version.